Aquaporin 4 in traumatic brain injury: from molecular pathways to therapeutic target

E Dadgostar, S Rahimi, S Nikmanzar, S Nazemi… - Neurochemical …, 2022 - Springer
… -1 α (HIF-1 α) sirtuin 2, NF-κB, Malat1, nerve growth factor … shown to attenuate brain edema,
maintain blood–brain barrier … vascular endothelial growth factor (VEGF) upon brain injury [63]…

[HTML][HTML] Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

L Manni, G Conti, A Chiaretti… - Neural Regeneration …, 2023 - ncbi.nlm.nih.gov
… with nerve growth factor, intranasally delivered to the brain … , attenuating, among others,
the effects of proNGF on hp-tau. … Continuous infusion of NGF in a rat model of TBI stimulates …

Acute intranasal treatment with nerve growth factor limits the onset of traumatic brain injury in young rats

L Manni, E Leotta, I Mollica, A Serafino… - British Journal of …, 2023 - Wiley Online Library
Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema
following traumatic brainIntranasal administration of nerve growth factor ameliorate beta-amyloid …

[HTML][HTML] Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of …

A Curatola, B Graglia, G Granata, G Conti, L Capossela… - Biology Direct, 2023 - Springer
… and aquaporins-4-induced oedema and lowered tau phosphorylation in injured rat brain. …
severe OHCA, such as attenuating amyloid β42 deposits and brain edema, inhibiting the …

[HTML][HTML] Intranasal delivery of nerve growth factor in neurodegenerative diseases and neurotrauma

L Manni, G Conti, A Chiaretti, M Soligo - Frontiers in Pharmacology, 2021 - frontiersin.org
… In astrocytes, NGF/p75NTR interaction attenuates the … of AD, using NGF brain-deprived
mice (AD11 mice), or multiple-… “Nerve growth factor in pediatric severe traumatic brain injury: …

Management of traumatic brain injury: from present to future

R Crupi, M Cordaro, S Cuzzocrea, D Impellizzeri - Antioxidants, 2020 - mdpi.com
Brain damage following traumatic injury is a result of direct … [121], while nerve growth factor
decreases brain edema and … They can also be inserted into the brain via intranasal delivery

Intranasal delivery: effects on the neuroimmune axes and treatment of neuroinflammation

EM Rhea, AF Logsdon, WA Banks, ME Erickson - Pharmaceutics, 2020 - mdpi.com
intranasal delivery of various compounds from growth factors to … Nerve growth factor (NGF)
is a neurotrophin that aids in … delivered intranasally and attenuated dopaminergic neuron loss …

[HTML][HTML] Intranasal human-recombinant NGF administration improves outcome in children with post-traumatic unresponsive wakefulness syndrome

A Gatto, L Capossela, G Conti, G Eftimiadi, S Ferretti… - Biology Direct, 2023 - Springer
… on neuronal function recovery after traumatic brain damage. … , the ability to reduce cerebral
edema, reducing inflammatory cascade, … and neuroinflammation in young rats. These results …

[HTML][HTML] Long-Term Intranasal Nerve Growth Factor Treatment Favors Neuron Formation in de novo Brain Tissue

N Colitti, F Desmoulin, A Le Friec, W Labriji… - Frontiers in Cellular …, 2022 - frontiersin.org
after the surgery, n = 4 rats died because of excessive edema… , to these needs by testing
intranasal delivery and a dose of … within brain injury can be remodeled by a growth factor toward …

[HTML][HTML] Aquaporin 4 regulation by ginsenoside Rb1 intervenes with oxygen-glucose deprivation/reoxygenation-induced astrocyte injury

YN Li, ZW Gao, R Li, YF Zhang, QS Zhu, F Huang - Medicine, 2019 - ncbi.nlm.nih.gov
… Rb1 treatment or AQP4 overexpression in rat astrocytes significantly attenuated the OGD/R-…
, nerve growth factor (NGF), and neurotrophic factor-3, which can reduce spinal cord edema